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Immunology news
Immunology
Researchers develop a new vaccine additive that creates a stronger, tunable immune response
Researchers at Stanford Engineering have developed a nanoparticle platform that could make existing vaccines more effective, including those for influenza, COVID-19, and HIV. In addition to helping vaccine candidates produce ...
12 hours ago
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Psychology & Psychiatry
Study ties alopecia to higher prevalence of autoimmune, psychiatric comorbidities
Patients with alopecia areata (AA) have a higher prevalence of autoimmune and psychiatric comorbidities at time of diagnosis as well as a higher risk for new-onset autoimmune and psychiatric comorbidities after diagnosis, ...
21 hours ago
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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive ...
21 hours ago
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Drug bypasses suppressive immune cells to unleash immunotherapy
By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments.
Aug 6, 2024
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Study shows Meteorin-like protein drains energy from T cells, limiting immune system's power to fight cancer
A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins ...
Aug 6, 2024
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Recurrent wheezing in children linked to 'silent' viral infections
Nearly a quarter of children with recurrent wheezing have "silent" lung infections that would be better treated with antiviral medications than commonly prescribed steroids that can carry lifelong side effects, new research ...
Aug 6, 2024
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Scientists probe molecular cause of COVID-19 related diarrhea, revealing potential treatments
Working with human stem cells that form a kind of "mini intestine-in-a-dish," Johns Hopkins Medicine scientists say they have found several molecular mechanisms for COVID-19-related diarrhea, suggesting potential ways to ...
Aug 6, 2024
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Researchers reveal why vaccines have lower efficacy in patients with multiple myeloma
Research carried out by a group from Cima and the Clínica Universidad de Navarra has described the composition of the immune system in blood samples from patients with multiple myeloma, by generating a new immunological ...
Aug 6, 2024
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MS changes the microbiome subtly but similarly, whether in US or Asia
Many studies have shown multiple sclerosis (MS) is associated with changes to the bacteria in a person's gut—but the changes reported were all over the map. Now, UConn researchers have analyzed the results of seven studies ...
Aug 6, 2024
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Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues. However, the immunosuppressive ...
Aug 6, 2024
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Study shows INT-1B3 inhibits distant tumor metastasis and significantly prolongs survival
A research paper has been published in Oncotarget titled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment ...
Aug 6, 2024
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Research explains why virus causing cold sores does not spread to devastating brain infection
More than half of us are carriers of chronic herpesvirus infections.
Aug 5, 2024
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Deaths from advanced lung cancer have dropped significantly since immunotherapy became standard-of-care
Since the first immunotherapy drug to boost the body's immune response against advanced lung cancer was introduced in the United States in 2015, survival rates of patients with the disease have improved significantly. That's ...
Aug 5, 2024
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Improved chemokine homing enhances CAR T–cell therapy for osteosarcoma
Chimeric antigen receptor (CAR) T–cell immunotherapy re-engineers a patient's immune cells to target cancer cells. While successful in some types of leukemia, the approach has yet to realize its potential against pediatric ...
Aug 5, 2024
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Study answers questions about long-term survivorship following CAR T treatment
Axicabtagene ciloleucel, commonly known as axi-cel, is an innovative immunotherapy that uses modified T cells to target and destroy cancer cells. Approved for patients who have not responded to at least two prior lines of ...
Aug 5, 2024
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Q&A: CAR T cell therapy offers a novel approach to pediatric cancer treatment
One of the most innovative treatments for pediatric cancer today is a novel form of targeted immunotherapy that was recently developed and is now increasingly being applied to pediatric cancer treatment: chimeric antigen ...
Aug 5, 2024
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FDA approves engineered cell therapy for treating rare sarcoma
The U.S. Food and Drug Administration (FDA) has granted accelerated approval for the immunotherapy afamitresgene autoleuecel (Tecelra, also known as afami-cel) for the treatment of adults with a rare soft tissue cancer called ...
Aug 5, 2024
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New hope for prostate cancer: New form of immunotherapy could prevent resistance to hormone therapy
A new form of immunotherapy using innovative nanoparticles can delay resistance to hormone therapy and help men with prostate cancer live longer.
Aug 5, 2024
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Scientists discover a population of macrophages that participate in alveolar regeneration
Researchers at the University of Liège (Belgium) have discovered a new population of macrophages, important innate immune cells that populate the lungs after injury caused by respiratory viruses. These macrophages are instrumental ...
Aug 2, 2024
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Scientists discover mast cells trap and use living neutrophils during allergic reactions
Known for their role in allergic reactions, mast cells have long been recognized as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy symptoms such as tissue ...
Aug 2, 2024
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Overcoming the limits of immunotherapies
CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the U.S. and a year later in Europe for treating acute lymphoblastic ...
Aug 2, 2024
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FDA approves CAR T cell treatment for resistant mantle cell lymphoma
Mantle cell lymphoma (MCL) is a rare and sometimes ruthless form of non-Hodgkin lymphoma. Even when treatment appears to be successful, the cancer often returns and is difficult to cure.
Aug 2, 2024
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T-cells with a license to kill viruses
A research group led by Kyoto University has produced the world's first pluripotent stem cell-derived killer T-cell drug to treat COVID-19. The University has filed a patent application ahead of full-scale drug development.
Aug 2, 2024
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New study shows polymersomes' potential in cancer immunotherapy
Within an international collaboration of 30 scientists, TU/e professors Jan van Hest and Willem Mulder are working on nanotechnological research to accurately stimulate the immune system. The TU/e team is focusing on the ...
Aug 1, 2024
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Using AI, researchers pioneer a potential new immunotherapy approach for treating glioblastoma
In an innovative study of glioblastoma, scientists used artificial intelligence (AI) to reprogram cancer cells, converting them into dendritic cells (DCs), which can identify cancer cells and direct other immune cells to ...
Aug 1, 2024
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