Link discovered between sensory neurons and spread of breast cancer: Anti-nausea medication may prevent it
Cancer doesn't grow in a vacuum—each tumor grows in a particular microenvironment within the body and spreads through a tangled web of vasculature and nerves. Scientists have come to understand that the most potent therapies ...
17 hours ago
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Genetic signatures provide prognostic information in colorectal cancer
Using a unique collection of genetic and clinical data for colorectal cancer, researchers at Uppsala University have revealed genetic new alterations and developed of a new molecular classifier of tumor variants. The finding ...
16 hours ago
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The battle against glioblastoma: Classifying molecular profiles for precision medicine
Glioblastoma multiforme (GBM) stands as a formidable adversary in oncology, characterized by its molecular complexity and relentless progression. Despite advancements, the high degree of tumor heterogeneity and its tendency ...
21 hours ago
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Pharmacogenomic score can personalize treatment of leukemia in children
For pediatric patients with acute myeloid leukemia (AML), a pharmacogenomics-based 10 single nucleotide polymorphism cytarabine (Ara-C) score (ACS10) can be used to tailor induction regimens, yielding improved outcomes, according ...
15 hours ago
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Study suggests an MRI may help doctors predict more aggressive prostate cancer in patients
New Corewell Health research suggests an MRI scan can help predict whether patients with intermediate-risk prostate cancer (cancer confined to the entire prostate) may have more aggressive cancer in five years. Knowing this ...
17 hours ago
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Dealing with runaway metastatic disease
A new editorial paper titled "How to deal with runaway metastatic disease?" has been published in Oncotarget.
12 hours ago
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FDA approves drug targeting brain cancer gene mutation
A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA). The promising new drug stems from a 2008 genetic discovery made at ...
17 hours ago
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FDA approves new therapy for glioma patients for first time in decades
Vorasidenib has been approved by the U.S. Food and Drug Administration (FDA) for patients with Grade 2 gliomas with IDH1 or IDH2 mutations.
21 hours ago
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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive ...
21 hours ago
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How an effective cancer therapy may damage the heart
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells. Blocking CTLA-4 with a specific antibody is an effective treatment ...
Aug 7, 2024
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Drug bypasses suppressive immune cells to unleash immunotherapy
By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments.
Aug 6, 2024
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Study shows Meteorin-like protein drains energy from T cells, limiting immune system's power to fight cancer
A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins ...
Aug 6, 2024
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Gestational diabetes does not increase risk of breast cancer, large Danish study finds
Women who develop gestational diabetes are not more likely to go on to be diagnosed with breast cancer, according to a study of almost three-quarters of a million mothers to be presented at this year's Annual Meeting of the ...
Aug 6, 2024
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US spends $43 billion annually on cancer screening
Screening for cancer saves lives, but a new report shows it comes with a hefty price tag: The United States spends at least $43 billion annually on tests that check for five major cancers.
Aug 6, 2024
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Researchers reveal why vaccines have lower efficacy in patients with multiple myeloma
Research carried out by a group from Cima and the Clínica Universidad de Navarra has described the composition of the immune system in blood samples from patients with multiple myeloma, by generating a new immunological ...
Aug 6, 2024
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Age impacts pharmacogenomics and treatment outcomes for most common form of leukemia
Acute lymphoblastic leukemia (ALL) affects both children and adults, but children have better chances to be cured, with long-term survival rates of over 85% compared to 50%–75% in adults.
Aug 6, 2024
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Prostate cancer: Can AI help to avoid unnecessary biopsies?
When the PSA is elevated: for which men is a biopsy necessary to confirm or rule out suspected prostate cancer? In a retrospective study, scientists from the German Cancer Research Center (DKFZ) and the Department of Urology ...
Aug 6, 2024
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Q&A: Researchers discuss identifying potential new protein targets for melanoma therapeutics
Yu-Hwa Huang, Ph.D. and Charles Yoon, MD, of the Department of Medicine and Department of Surgery at Brigham and Women's Hospital respectively, are co-lead authors of a paper titled "High-dimensional mapping of human CEACAM1 ...
Aug 6, 2024
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Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues. However, the immunosuppressive ...
Aug 6, 2024
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Study shows INT-1B3 inhibits distant tumor metastasis and significantly prolongs survival
A research paper has been published in Oncotarget titled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment ...
Aug 6, 2024
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New study shows 1 in 10 cancer patients are spending $10,000 in out-of-pocket health care costs in Australia
The financial burden of health care in Australia can be high, particularly for people diagnosed with cancer. A new study from the Daffodil Centre has shown one in ten people with cancer in NSW spends more than $10,000 on ...
Aug 6, 2024
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Study finds noncoding RNAs dysregulated in several human cancers
Northwestern Medicine scientists have discovered new insights into the production and regulation of a class of noncoding RNAs and how alterations in their signatures diversify and modulate the transcriptome of three major ...
Aug 5, 2024
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Proposed lung cancer screening guideline could eliminate racial disparities, allow for early detection
Early detection of lung cancer through low-dose computed tomography screening is one of the most promising strategies to reduce lung cancer mortality among high-risk individuals.
Aug 5, 2024
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